Abstract
1. 1.|Catecholamines and their final metabolites were determined quantitatively in urine of guinea-pigs ( Cavia aperea porcellus) during thermal adaptation by means of high performance liquid chromatography (HPLC) with electrochemical detection (ECD). 2. 2.|The daily release of free noradrenaline (NA) and 3-methoxy-4-hydroxyphenylglycole (MHPG) increased in cold adapted animals (5°C) up to 500% at the beginning of the third week of cold exposure (in comparison to animals kept at 22°C). Warm adapted animals (28°C) reduced NA and MHPG excretion by nearly 50%. 3. 3.|No significant changes in excreted amounts of adrenaline (A), dopamine (DA) and homovanillic acid (HVA) could be detected during thermal adaptation. 4. 4.|From these data it can be concluded that the exposure of warm adapted guinea-pigs to cold may lead to a 10 times higher peripheral release and turnover of NA.
Published Version
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