Changes in oxidative stress markers and cardiometabolic risk factors among Roux-en-Y gastric bypass patients after 3- and 12-months postsurgery follow-up

Abstract

BackgroundEvidence shows potential reduction in oxidative stress after Roux-en-Y gastric bypass. However, this outcome can vary, with postsurgery time, type of markers significantly altered, and possible relation with cardiometabolic risk markers, thus indicating the need for more studies. ObjectiveTo evaluate changes in oxidative stress and its relation with cardiometabolic risk markers in Roux-en-Y gastric bypass patients after 3 and 12 months postsurgery. SettingFederal University of Viçosa, Brazil. MethodsAll data were collected before surgery and after 3 and 12 months postsurgery. Biochemical data were collected, and insulin resistance was determined by homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol. Additionally, catalase, superoxide dismutase, ferric-reducing antioxidant power, nitric oxide, carbonylated protein, and malondialdehyde were analyzed. ResultsAfter 3 months postsurgery, excess weight loss was 46%. It increased to 82% after 12 months. We observed a significant reduction in levels of serum insulin, triglycerides, homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol indices and nitric oxide, throughout the entire study period. Also, reduced levels of total cholesterol, low-density lipoprotein, serum glucose, malondialdehyde, and superoxide dismutase were observed at 3 and 12 months postsurgery compared with baseline. On the other hand, reduction in ferric-reducing antioxidant power occurred only at 3 months postsurgery. We also observed that nitric oxide was positively correlated with triglycerides, percent excess weight loss, total cholesterol/high-density lipoprotein cholesterol, and triglyceride/glucose index. ConclusionRoux-en-Y gastric bypass is able to reduce oxidative stress, insulin resistance, and improve lipid profile after 3 and 12 months postsurgery. Furthermore, changes in oxidative stress and cardiometabolic risk markers are correlated.