Abstract
Changes in the neuropeptide expression of sensory neurons, related to functional modulation, have been widely reported both following physical injury in vivo [4, 23], and after toxic insult in vitro and in vivo [7]. The current immunocytochemical study aimed to monitor the neuropeptide status of neuronal cultures prepared from adult mouse dorsal root ganglia (DRG), and to ascertain whether changes occurred following treatments with 0.1–1 μM methylmercury (MeHg). Proportions of both substance P (SP) and calcitonin gene related peptide (CGRP) containing neurons increased significantly, and were maintained throughout the 24 h exposure period. In contrast the numbers of somatostatin (SOM)-ir neurons decreased. Substance P- and CGRP-ir neuron increases may be related to nociceptive responses, whereas the decreases in SOM containing neurons could reflect a differential loss in this subset of sensory neurons.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
