Changes in neurons of certain regions of the brain under the influence of nivaline

Abstract

The study was devoted to changes in the neurons of certain parts of the brain in rats and cats under the influence of nivaline. Nivaline was injected subcutaneously and intramuscularly in 1, 6, and 12 mg/kg doses. It was found that nivaline injections in small doses were followed by an increase in the number of hypo- and hyperchromatic cells in the brain cortex and the reticular formation of the brain stem, these cells being represented in various correlations in different parts of the brain cortex. In the subcortical formations, the central gray matter of the midbrain, and the corpora quadrigemina the changes were mainly manifested by swelling, chromatolysis and vacuolization of the neuron cytoplasm. The changes in the hypothalamus neurons resembled those in the reticular formation of the brain stem. With an increase in nivaline dosage, changes in the neurons and particularly their dendrite systems increased too. Upon injection of large doses of the preparation the structural changes of neurons in different analyzer systems showed similar features.