Abstract
BackgroundA common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.MethodsIn this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals.ResultsADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation.ConclusionsFindings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
Highlights
A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT)
Based on findings from our previous study demonstrating a decline in spatial reasoning abilities in healthy men undergoing ADT [11], the aim of this study was to examine if neural activation changes were evident in response to androgen deprivation while performing spatial reasoning and spatial memory tasks using functional magnetic resonance imaging
Seven controls and five ADT patients were included in the imaging analysis
Summary
A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). Psychiatric changes can include depression and anxiety [8] and cognitive problems can include impairments in verbal memory [9,10], spatial reasoning [11] and attention [12]. Given these cognitive and medical side effects of ADT understanding the immediate and long-term consequence of treatment is essential
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