Abstract
It is generally assumed that there is a direct relation between changes in myocardial blood flow and myocardial function. A severe reduction in myocardial blood flow, as during ischemia, however, does not necessarily result in a profound fall in myocardial fiber shortening at all sites in the region affected. On the contrary, under certain circumstances a limited decrease in blood flow in the epicardial layers of the left ventricular wall may result in complete cessation of fiber shortening in these layers. Important aspects that have to be considered, when studying the relation between changes in myocardial blood flow and function, are the metabolic consequences of the flow reduction and the loading conditions of the myocardium. Evenso restoration of myocardial blood flow following ischemia does not always result in recovery of myocardial function.
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