Abstract
The molecular characteristics of 480 Mycoplasma pneumoniae polymerase chain reaction-positive specimens (331 were previously reported and 149 were newly reported) collected from pediatric patients in Beijing, China, between 2003 and 2015 were analyzed. Genotype M4-5-7-2/P1 were the most prevalent across the 13-year study period, although the isolation and mutation rates for this genotype varied between the periods 2003–2007, 2008–2013, and 2014–2015. In addition, there was a close association between the M4-5-7-2 genotype and macrolide resistance.
Highlights
Mycoplasma pneumoniae is a common bacterial pathogen that causes upper and lower respiratory tract infections in humans, children and young adults [1]
We analyzed the molecular characteristics of M. pneumoniae specimens directly from 480 polymerase chain reaction (PCR)-positive respiratory specimens collected at the Affiliated
(19/23) contained M. pneumoniae identified as P1 type 1, while 17.4% (4/23) specimens were
Summary
Mycoplasma pneumoniae is a common bacterial pathogen that causes upper and lower respiratory tract infections in humans, children and young adults [1]. Analysis of the molecular characteristics of specimens collected over this period is very important. The most prevalent M. pneumoniae genotypes, along with drug resistance profiles, can differ between regions and countries [6, 7]., and even within the same region, type-shifts in predominant P1 genotypes have been recorded in Japan at intervals of about 10 years [8]. There is little epidemiological information regarding trends in P1 and multiple locus variable-number tandem repeat analysis (MLVA) genotypes and macrolide resistance mutations in the 23S rRNA gene of M. pneumoniae in China. This study aimed to elucidate changes in the molecular characteristics of M. pneumoniae specimens in China over a
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