Abstract
Ultrastructural features of mitochondria in nickel sulfide-induced primary rat rhabdomyosarcomas were compared with those of muscle tissues exposed to nickel sulfide in amounts suboptimal for inducing tumors. Tumor cell mitochondria exhibited conformational changes, accumulation of electron dense granules, and elaboration of cristae which appeared to coalesce and form wavy or parallel stacks. Some of these mitochondria were extremely enlarged and appeared to show degenerative changes including disruption of the outer and inner membranes and/or complete replacement of the cristae with 50 to 60 A thick filaments. Some of these changes were also noted in rat muscle tissues exposed to nickel sulfide for short duration, suggesting that mitochondria altered in response to nickel sulfide are capable of prolonged survival. It would appear that some of the mitochondrial changes induced by nickel sulfide in adult skeletal muscle are adaptive modifications maintained in tumor cells which result from repeated divisions of dedifferentiated muscle cell derivatives.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
