Abstract
Acute, inflammatory processes contribute to the fact that conventionally pathogenic and pathogenic microorganisms colonize the mucous membranes of the small intestine and form biofilms, can become a source of bacterial toxin, which, when the epithelial layer breaks, penetrates to the lymphatic and blood systems, contributing to the formation of sepsis. The barrier function of the epithelium is critical in the development of inflammatory bowel diseases, while normal functioning requires a constant balance between reactivity and tolerance to microorganisms of the intestinal lumen. Increased permeability of the intestinal mucosa is the main risk factor for the spread of bacteria. Epithelium, being an essential element of tissue barriers, provides selective transport for the movement of ions and macromolecules, and also creates an obstacle for their penetration into the underlying tissues. Control of the permeability of the epithelial layer is carried out by the apical intercellular complex - tight contacts, which comprise proteins of the claudine family. Intestinal flora affects the sensory, motor and immune functions of the intestine, and also interacts with higher nervous centers. mmunosuppressive processes are one of the main causes of destabilization of the barrier function, intestine, and brain.
Highlights
Acute, inflammatory processes contribute to the fact that conventionally pathogenic and pathogenic microorganisms colonize the mucous membranes of the small intestine and form biofilms, can become a source of bacterial toxin, which, when the epithelial layer breaks, penetrates to the lymphatic and blood systems, contributing to the formation of sepsis
The barrier function of the epithelium is critical in the development of inflammatory bowel diseases, while normal functioning requires a constant balance between reactivity and tolerance to microorganisms of the intestinal lumen
The purpose of this work was to study the effect of the complex positions of dextran sodium sulfate on the intestinal microbiota of mice, to obtain a model of nonspecific ulcerative colitis (NUC), to interrelate the axis of the intestine-blood-brain, the ways of affecting some zeolites of this domestic production, the immune active and anti-inflammatory properties of zeolites, found in the regions of Armenia in the experimental models of the NUC
Summary
Inflammatory processes contribute to the fact that conventionally pathogenic and pathogenic microorganisms colonize the mucous membranes of the small intestine and form biofilms, can become a source of bacterial toxin, which, when the epithelial layer breaks, penetrates to the lymphatic and blood systems, contributing to the formation of sepsis. The sensory neurons of the vagus nerve are contacted by submucosal immune cells and project the nerve endings into the mucous membrane of the gastrointestinal tract, the site of direct interaction between the organism and the pathogen. The detection of Fos protein, synthesized by neurons including and markers of functional activity, in the sensory neurons of the nerve after inoculation of bacteria, testified that this connection is accomplished by the vagus nerve.[4,5] The death of intestinal neurons and glia damage with alteration of the expression of the acidic fibrillar protein and increased expression of the molecules of the main histocompatibility complex of the second class were noted in Crowns’ disease, ulcerative colitis, necrotizing enterocolitis and diabetes.[6]
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