Abstract
AbstractMany of the histological characteristics of neuromuscular disorders, including central core lesions and nemaline rods, can be produced experimentally by tenotomy of the soleus muscle in the rat. Using the freeze fracture technique, a decrease in the number of intramembrane particles of both the P and E faces of the plasma membranes of tenotomized soleus muscle fibers was observed. While many of the degenerative changes which occur after tenotomy are known, the causes of the degeneration are still unknown. The decrease in intramembrane particles may reflect some significant change in the function of the plasma membrane resulting in the appearance of the degenerative changes which follow tenotomy.
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