Abstract
ObjectiveCardiovascular disorders are common in patients with panic disorder (PD), usually mediated by platelets. The present study was conducted to evaluate oxidative stress conditions and complete analysis of blood cells in patients with PD.Setting and Sample PopulationSixty healthy individuals and 60 patients were included in the study. Whole blood and serum samples were obtained from patients and controls.Materials & MethodHematological studies, including blood cells count, hemoglobin, and hematocrit, were carried out on whole blood samples. In addition, oxidative stress indices including total antioxidant capacity, free oxygen species, and malondialdehyde concentration were measured in serum samples.ResultsResults showed that patients with PD had a significant increase in mean platelet volume index (MPV), platelet distribution width (PDW), red blood cell distribution width (RDW), and mean corpuscular hemoglobin concentration (MCHC) compared with healthy subjects (p < .05). Also, oxidative stress indices were significantly elevated in patients with PD compared with control group (p < .05).ConclusionElevated MPV is a hematologic indicator for patients with PD. This disorder may be caused by impaired serotonin metabolism, resulting in increased oxidative stress, as well as in platelet serotonin transporters. Regarding elevated oxidative stress, the risk of cardiovascular complications is high in patients with PD.
Highlights
Panic disorder (PD) is one of the most common serious disorders in the field of psychological illness characterized by sudden and unexpected attacks (Freire, Zugliani, Garcia, & Nardi, 2016)
The current study found that oxidative stress is elevated in patients with PD, which was accompanied with changes in mean platelet volume index (MPV), platelet distribution width (PDW), and red blood cell distribution width (RDW)
The results of this study showed that people with PD experience higher levels of oxidative stress and lower MPV and PDW values compared with healthy subjects
Summary
Panic disorder (PD) is one of the most common serious disorders in the field of psychological illness characterized by sudden and unexpected attacks (Freire, Zugliani, Garcia, & Nardi, 2016). Studies have shown that platelets in peripheral blood reflect serotonin metabolism in the nervous system and the function of serotonergic neurons. Serotonin is an important factor in the pathophysiology of neurodegenerative diseases such as anxiety and plays an important role in platelet aggregation (Camacho & Dimsdale, 2000) Platelets at their surface express a variety of serotonin receptors, including 5-HT2A and 5HT3. Increased oxidative stress elevates the risk of cardiovascular disease directly and indirectly through the activation of platelets to produce thrombosis (Freedman, 2008). Oxidative stress can cause many disorders such as damage to RBC, damage to DNA and proteins, alteration structure of LDL, and produced oxidized LDL It elevates risk of cardiovascular disease (Amin et al, 2020; Flora, 2020). The aim of the present study was to survey the changes in platelet and hematologic indices and their relation with oxidative stress in patients with PD in comparison with healthy subjects
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