Abstract
Morbid obesity has a direct impact on the development of cardiovascular disease. One-anastomosis gastric bypass (OAGB) is an effective surgical technique for the control of body weight and the reduction of cardiovascular risk. This work examines the change in weight loss, lipid profile and cardiovascular risk in 100 patients (71 women, 29 men), mean age 42.61 ± 11.33 years at 3, 6, 9, 12, 18 and 24 months after OAGB. At 24 months post-surgery, mean body weight was significantly reduced compared to pre-operative values (116.75 ± 22.19 kg vs. 69.66 ± 13.07 kg), as were mean total cholesterol (201.86 ± 44.60 mg/dL vs. 172.99 ± 32.26 mg/dL), LDL (Low-Density Lipoprotein) cholesterol (126.90 ± 39.81 mg/dL vs. 96.28 ± 26.99 mg/dL), triglycerides (138.05 ± 78.45 mg/dL vs. 76.04 ± 30.34 mg/dL) and cardiovascular risk (total cholesterol/HDL (High-Density Lipoprotein) cholesterol: 4.32 ± 1.24 vs. 2.93 ± 0.71), while the mean HDL cholesterol concentration was significantly higher (49.09 ± 14.16 mg/dL vs. 61.98 ± 14.86 mg/dL) (all p < 0.001). In conclusion, OAGB surgery led to significant reductions in body weight, a significant improvement in the lipid profile, and a reduction in cardiovascular risk.
Highlights
The World Health Organization (WHO) defines obesity as abnormal or excessive fat accumulation that may affect health [1]
The condition increases the risk of developing cardiovascular disease, diabetes, musculoskeletal disorders and cancer in a manner proportional to the increase in body mass index (BMI)
The aim of the present work was to examine the change over a 24-month period in weight loss, lipid profile and cardiovascular risk in patients who had undergone One-anastomosis gastric bypass (OAGB)
Summary
The World Health Organization (WHO) defines obesity as abnormal or excessive fat accumulation that may affect health [1]. The condition increases the risk of developing cardiovascular disease, diabetes, musculoskeletal disorders and cancer in a manner proportional to the increase in body mass index (BMI). More than 1.9 billion people over 18 years of age were overweight in 2016; 650 million of them were obese [1]. According to the Global Burden of Disease Project, in 2015 excess bodyweight accounted for a global 4 million deaths and 120 million disability adjusted life years. Almost 70% of deaths related to high BMI were caused by cardiovascular disease, and over 60%. Of those deaths were among obese people [2]. Overweight, obesity and dyslipidemia are all modifiable risk factors of cardiovascular disease [3,4]. The treatment of choice for obesity depends upon the type of obesity and
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