Abstract
This cross-sectional study calculates the increase in clinical cancer knowledge represented in the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines from 1996 to 2019.
Highlights
The last century has seen substantial increases in the generation of knowledge pertaining to clinical cancer care.[1]
The study follows the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline for cross-sectional studies and was conducted with permission from the National Comprehensive Cancer Network (NCCN)
We evaluated total references cited in the discussion section of each guideline document as well as the number of decision paths present in the flowchart sections of guideline documents from 1996 and 2019
Summary
The last century has seen substantial increases in the generation of knowledge pertaining to clinical cancer care.[1]. The NCCN has published regularly updated Clinical Practice Guidelines in Oncology (NCCN Guidelines) that cover recommended management for 97% of patients with cancer. The guidelines are used by as many as 95% of oncologists in the US in clinical practice and are relied on by public and private insurers to determine oncology coverage policies.[2] Since the establishment of the NCCN Guidelines, cancer management options have continued to increase in quantity and complexity because of advances in personalized medicine, novel therapeutics, and technology. We sought to quantify the increase in clinical cancer knowledge represented in the NCCN Guidelines since the turn of the 21st century
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