Changes in left ventricular blood flow during diastole due to differences in chamber size in healthy dogs

Katsuhiro Matsuura,Kazumi Shimada,Kotomi Sato,Takeshi Iso,Ken Takahashi,Akiko Uemura,Kana Yazaki,Zeki Yilmaz,Seijirow Goya,Ryou Tanaka

doi:10.1038/s41598-019-57180-6

Abstract

Vorticity is a novel index that reflects diastolic function of left ventricle. The size of the ventricle can influence the ventricular diastolic blood flow. We evaluated effect of ventricular size on diastolic function and diastolic intracardiac blood flow using a particular species of dogs, which has a wide range of body size. Vector flow mapping was used for evaluation of intracardiac blood flow, and intraventricular pressure gradient (IVPG) was used for evaluation of diastolic function. 58 dogs weighing 1.3–42.3 kg were included in this study. Vorticity was found to be inversely proportional to the length of the ventricular chamber. Intraventricular pressure difference was positively correlated with the length of the left ventricle, whereas IVPG was not. This study showed that the vorticity is influenced by the size of the left ventricle independently of other factors. To evaluate the hemodynamic state of each individual appropriately by using vorticity and IVPD, ventricular size should be taken into account especially in the field of veterinary medicine and human pediatric and adolescent cardiology.

Highlights

Vorticity is a novel index that reflects diastolic function of left ventricle
In order to verify the utility of index derived from intracardiac flow analysis such as vorticity, it is necessary to elucidate the influence of the heart size on the intracardiac blood flow and clarify the causal relation between the heart size and the diastolic function
We evaluated the effect of ventricular size on diastolic function and diastolic intracardiac blood flow using dogs, which had a diversity of body size

Summary

Introduction

Vorticity is a novel index that reflects diastolic function of left ventricle. The size of the ventricle can influence the ventricular diastolic blood flow. We evaluated effect of ventricular size on diastolic function and diastolic intracardiac blood flow using a particular species of dogs, which has a wide range of body size. In order to verify the utility of index derived from intracardiac flow analysis such as vorticity, it is necessary to elucidate the influence of the heart size on the intracardiac blood flow and clarify the causal relation between the heart size and the diastolic function. Understanding the relation between the heart size and intracardiac blood flow enables us to utilize vorticity especially in the field of veterinary medicine and human pediatric and adolescent cardiology. We used dogs to examine the difference in diastolic blood flow depending on the heart size. This study will show the effect of the heart size on the intraventricular blood flow and the diastolic function

Methods

Results

Conclusion