Abstract
The present study indicates that severe hemorrhagic shock of significant duration is associated with elevation of the internal sodium concentration of red blood cells. The magnitude of these changes appears to be a function of both the severity and duration of the shock process and seems to be well correlated with changes in clinical course when sequential sampling procedures are utilized. Present data are insufficient to determine the exact etiology of the red cell changes observed in profound shock. However, it can be speculated that the observed elevation in internal sodium concentration in this group of patients is only one manifestation of a process involving a generalized change in cellular composition and function during hemorrhagic shock.
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