CHANGES IN INDICATORS OF ANTIOXIDANT PROTECTION IN CHRONIC ENTEROCOLITIS AND THEIR CORRECTION

Abstract

Chronic enterocolitis is one such disease, the basis of which is a combination of elements of inflammation and dystrophy of the mucous membrane with functional disorders of the small and large intestines. In the pathogenesis of enterocyte intoxication, the main role is played by oxidative stress, which is characterized by a violation of the metabolism of substances and energy, the accumulation of active damaging agents, initiating pathological changes in cells, and leading to the development of various pathological conditions. Therefore, our work aimed to determine the effectiveness of the use of antioxidant therapy (emoxipin) in experimental chronic enterocolitis in rats. The study was performed on 18 purebred white male rats, which were divided into 3 groups: the control group - 6 rats (intact animals), the 1st experimental group – 6 animals with chronic enterocolitis, the 2nd - 6 rats with chronic enterocolitis, which were subjected to emoxipin therapy. Chronic enterocolitis was reproduced by the free access of animals to a 1.0% solution of carrageenan in drinking water for 1 month. Animals with chronic enterocolitis were injected with 60 mg/kg of emoxipin intraperitoneally once a day for 10 days. Superoxide dismutase and catalase activity were determined in 10% homogenate of small intestine tissue. In the 1st experimental group, a significant decrease in superoxide dismutase activity by 42.7% and catalase by 57.9% (p<0.05) was noted, compared to the control. In the 2nd experimental group, the activity of SOD increased statistically significantly both about the control by 40.9% and about the 1st experimental group - by 146.8%, the activity of catalase was similar: about the control, it increased by 44.3%, in relatiaboutexperimental group – by 242.4% (р<0.05). Therefore, emoxipin is an effective drug of choice for chronic enterocolitis.