Changes in incidence of cystic fibrosis

Abstract

Prevalence, Neonatal Characteristics, and First-Year Mortality of Down Syndrome: A National StudyThe Journal of PediatricsVol. 152Issue 1PreviewTo determine the prevalence, neonatal characteristics, and first-year mortality in Down syndrome (DS) among children in the Netherlands. Full-Text PDF Is Down Syndrome a Disappearing Birth Defect?The Journal of PediatricsVol. 152Issue 1PreviewTo assess trends in the prevalence of Down syndrome (DS) from 1986 to 2004 in Victoria, Australia (population ∼5 million). Full-Text PDF Time Trends in Birth Incidence of Cystic Fibrosis in Two European Areas: Data from Newborn Screening ProgramsThe Journal of PediatricsVol. 152Issue 1PreviewTo determine the incidence of cystic fibrosis (CF) and its time trends over a 16-year period (1990 to 2005) in 2 European regions with a long history of newborn screening (NBS) for CF, and to investigate the impact of some external factors. Full-Text PDF How Far Can Prenatal Screening Go in Preventing Birth Defects?The Journal of PediatricsVol. 152Issue 1PreviewThe ideal screening program would have perfect sensitivity and specificity in detecting the condition of interest, the health condition being detected would be of substantial clinical and public health importance, once detected there would be effective and acceptable action to prevent the adverse outcome, and the health care community and public would fully embrace the strategy. Although screening for serious birth defects that result from single gene defects may not attain that standard of perfection, they come closer than perhaps any other health condition. Full-Text PDF