Abstract
Hypothalamic monoamine oxidase (MAO) activity displayed biphasic responses to administration of estradiol-17β (E 2) depending on season. Lower doses of 0.05 and 0.10 μg/g BW of E 2 had enhanced enzyme activity and higher doses (0.5 and 1.0 μg/g BW) depressed it significantly in preparatory season. In prespawning phase, the lowest dose of 0.05 μg/g BW of E 2 was stimulatory and the higher doses were inhibitory to MAO activity. In postspawning season, lower doses (0.05 and 0.10 μg/g BW) of E 2 failed to elicit any significant change in enzyme activity whereas the higher doses (0.5 and 1.0 μg/g BW) elevated it significantly. Administration of clomid (5, 10, and 20 μg/g BW) inhibited MAO activity in a dose-dependent manner during all the three seasons. The results show that E 2 may participate in feedback control of gonadotropin secretion by modifying monoaminergic activity at the level of oxidative deamination by MAO.
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