Abstract
It has been shown long time ago that morphine causes hyperthermia in rats in low doses, as well as hypothermia in high doses. The present study has investigated effect of morphine on body temperature in rats after chronic administration, and changes of the serotonin level in rat hypothalamus after acute and chronic administration of morphine. Body temperature was measured with thermistor probes (TX8) inserted rectally, and monitored on multichannel recorder Thermex 16. Single administration of morphine (3 mg/kg, i.p.) produced hyperthermia in rats with maximum between 90 min and 120 min after drug application. Repeated injection of morphine (3 mg/kg/day, i.p.) over a 9-week period caused similar hyperthermic reaction in rats, but maximal effect was found between 60 min and 90 min after drug application (the time to appearance of the maximal hyperthermal effect was significantly shortened). These data are in correspondence with the changes of hypothalamic serotonin levels observed. After chronic administration of morphine the serotonin level in rat hypothalamus was increased.
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