Abstract
Objective To observe changes in hepatic microcirculation perfusion after acute carbon monoxide poisoning and effects of hyperbaric oxygen (HBO) on hepatic microcirculation by using laser Doppler blood perfusion imager. Methods Ninety Wistar rats were randomly divided into 9 groups: the control group, the CO exposure group which was subdivided into the CO exposure day 1, 3, 7 and 12 groups (or the CO day 1 group, the CO day 3 group, the CO day 7 group and the CO day 12 group), the CO exposure + HBO group which was subdivided into CO exposure + HBO therapy day 1, 3, 7 and 12 groups (or the HBO day 1 group, HBO day 3 group, HBO day 7 group and HBO day 12 group). Levels of hepatic and intestinal mucosa microcirculation perfusion were detected by using laser blood perfusion imager. Results In the control group, the CO day 1 group and the HBO day 1 group, the level of hepatic microcirculation perfusion was significantly lower than that of intestinal mucosa microcirculation perfusion. Statistical significance could be seen when comparisons were made between them(P 0.05). Conclusions Laser Doppler blood perfusion imager could detect changes in the level of hepatic microcirculation perfusion. Acute carbon monoxide poisoning could obviously decrease the level of hepatic microcirculation perfusion, but HBO treatment could help to improve hepatic microcirculation disturbance. Key words: Acute carbon monoxide poisoning; Hyperbaric oxygen; Hepatic; Microcirculation; Laser Doppler blood perfusion imager
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