Abstract
Melodic Intonation Therapy (MIT) has proved to be an effective treatment in severe Broca's aphasia. It has been suggested that due to its musical/prosodic content, it activates the intact right hemisphere which may have latent linguistic capabilities. We studied the effects of MIT vs. ordinary repetition performance on hemispheric brain perfusion as measured by single photon emission computed tomography (SPECT) in three aphasic patients. Two of them suffered from nonfluent aphasia but were nevertheless poor responders to MIT training. None of the three patients showed relatively higher right hemisphere activation during MIT. In contrast, one nonfluent patient showed increased left hemisphere activation and the other one exhibited a mixed activation pattern. Either the right hemisphere activation hypothesis is incorrect or it holds only for the hitherto unexamined good responders to MIT. If the latter alternative turned out to be correct, brain activation measurements in MIT candidates could have predictiv...
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