Abstract
Abstract Background: The antioxidant defense system has been subject to investigations in various cardiovascular diseases. The studies of its status in paroxysmal atrial fibrillation are scarce. The enzyme glucose-6-phosphate dehydrogenase is the main source of reducing equivalents and its activity is crucial for the antioxidant defense system of the cell. Purpose: To study the activity of glucose-6-phosphate dehydrogenase in dynamics as an indicator of the antioxidant defense system in patients with paroxysmal atrial fibrillation (<48 hours). Patients and methods: The enzyme was studied in erythrocytes of 51 patients (59.84±1.60, 26 males) immediately after hospitalization, 24 hours and 28 days after sinus rhythm restoration. It included also 52 healthy controls (59.50±1.46, 26 males), matching the patients by gender and age. The rhythm regulation was achieved by propafenone . The enzyme activity was determined spectrophotometrically. Results : The mean duration of atrial fibrillation episodes prior to hospitalization was 8.1 hours, the majority of the patients being hospitalized on the 5
Highlights
It is known that the changes in the oxidant status of the organisms play a significant role in the pathogenesis of a number of cardiovascular diseases [1,2,3,4]
In the early hours of its clinical manifestation, paroxysmal atrial fibrillation is associated with reduced glucose-6phosphate dehydrogenase activity, which persists after sinus rhythm restoration and is slowly increased with time
Future studies would allow for determination of the precise role of the antioxidant defense system in the disease pathogenesis as well as its significance for the disease prevention and treatment
Summary
It is known that the changes in the oxidant status of the organisms play a significant role in the pathogenesis of a number of cardiovascular diseases [1,2,3,4]. The paroxysmal atrial fibrillation (PAF) is one of the five types of atrial fibrillation according to its clinical presentation and duration. AF paroxysms may continue up to 7 days, clinically important are the first 48 hours which allow for acute regulation of the rhythm. PAF comprises between 25% and 62% of all cases of atrial fibrillation (AF) [8], the risk of stroke and thromboembolic. The antioxidant defense system has been subject to investigations in various cardiovascular diseases. The studies of its status in paroxysmal atrial fibrillation are scarce. The enzyme glucose-6phosphate dehydrogenase is the main source of reducing equivalents and its activity is crucial for the antioxidant defense system of the cell. Purpose: To study the activity of glucose-6-phosphate dehydrogenase in dynamics as an indicator of the antioxidant defense system in patients with paroxysmal atrial fibrillation (
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