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Abstract
Changes in glucose-6-phosphatase activities in the liver and kidney were investigated in rats after ip administration of a large dose of fluoride (NaF, 35 mg/kg body wt). The glucose-6-phosphatase activity in the liver and kidney of fluoride-treated rats increased 2.37 and 3.42 times that of respective control values. These elevations in hepatic and renal glucose-6-phosphatase activity were suppressed by pretreatments of actinomycin D or cycloheximide.
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