Abstract
Abstract— The size of the free fatty acid pool in rat brain was significantly increased following convulsions induced by pentylenetetrazol as well as by electroconvulsive shock. Other convulsants such as d‐methionine‐dl‐sulphoximine and the dibutyryl analog of adenosine 3′,5′‐monophosphate did not alter the levels of free fatty acids.Diethyl ether anaesthesia suppressed the stimulatory effect of electroshock on the generation of free fatty acids in brain, but the effect was not seen with the anaesthetic pentobarbitone sodium. The lack of an inhibitory effect of either anaesthetic on the free fatty acid production which was induced in brain by ischaemia supported the view that the action of electroshock was not merely the result of anoxia.The prominent increase in size of the free fatty acid pool in brain thus appeared to be specific for electroshock‐ and pentylenetetrazol‐convulsed rats.We have proposed that the changes in the free fatty acids might be involved in the regulation of membrane functioning.
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