Abstract
Objectives To assess the effects of androgen deprivation therapy on body composition in men with nonmetastatic prostate cancer. Methods In a multicenter study, men with Stage M0 prostate cancer were prospectively evaluated during initial androgen deprivation therapy (gonadotropin-releasing hormone agonist or bilateral orchiectomy). The main outcomes were changes in weight, percentage fat mass, and percentage lean mass from baseline to 12 months. Results Seventy-nine subjects were assessed. Serum testosterone concentrations decreased by 79.7% ± 3.0% ( P <0.001). Weight increased by 1.8% ± 0.5% ( P <0.001). The percentage fat mass increased by 11.0% ± 1.7%, and the percentage lean mass decreased by 3.8% ± 0.6% ( P <0.001 for each comparison). Conclusions Androgen deprivation therapy increased weight and fat mass and decreased lean mass in men with nonmetastatic prostate cancer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
