Changes in fat and lean body mass during androgen-deprivation therapy for prostate cancer

Abstract

Objectives To assess the effects of androgen deprivation therapy on body composition in men with nonmetastatic prostate cancer. Methods In a multicenter study, men with Stage M0 prostate cancer were prospectively evaluated during initial androgen deprivation therapy (gonadotropin-releasing hormone agonist or bilateral orchiectomy). The main outcomes were changes in weight, percentage fat mass, and percentage lean mass from baseline to 12 months. Results Seventy-nine subjects were assessed. Serum testosterone concentrations decreased by 79.7% ± 3.0% ( P <0.001). Weight increased by 1.8% ± 0.5% ( P <0.001). The percentage fat mass increased by 11.0% ± 1.7%, and the percentage lean mass decreased by 3.8% ± 0.6% ( P <0.001 for each comparison). Conclusions Androgen deprivation therapy increased weight and fat mass and decreased lean mass in men with nonmetastatic prostate cancer.