Abstract
1 PT and 1 PT variant A clonal cell lines, both derived from the same neuroendocrine positive, undifferentiated large cell lung carcinoma, showed differences in their morphology, DNA content, presence of desmosomes and expression of NCAM and desmoplakin. Colonies of cells which morphologically resembled 1 PT variant A cells arose in cultures of the 1 PT clonal line following prolonged cultivation. Such transitions in cloned cells of NSCLC origin have not previously been reported. This transition was associated with increased expression of desmoplakin and downregulation of NCAM. A converse transition of 1 PT variant A cells to 1 PT-like cells could not be demonstrated.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
