Abstract
Background Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced liver injury has markedly increased. Methods We conducted a retrospective review of 82,562 hospitalized patients diagnosed with liver cirrhosis in Beijing 302 Hospital from 2002 to 2013. Results The top four etiologies of cirrhosis were HBV, HCV, ALD, and autoimmune liver disease. The percentage of HBV cirrhosis decreased from 81.53% in 2002 to 66.0% in 2013, whereas the frequency of alcoholic cirrhosis increased from 3.34% in 2002 to 8.40% in 2013. Females (84.34%) accounted for the majority of cirrhotic patients with autoimmune liver diseases. Males accounted for 80.16% of HBV cirrhosis patients and 98.02% of alcoholic cirrhosis patients. Conclusion In Beijing 302 Hospital, the top four etiologies of cirrhosis were HBV, HCV, ALD, and autoimmune liver disease. Over the last 12 years, the prevalence of HBV cirrhosis has decreased gradually, whereas that of alcoholic cirrhosis has increased significantly.
Highlights
Recent years, viral hepatitis, especially chronic hepatitis B (CHB), is still a main reason of liver-related morbidity and mortality in China
The most common etiologies of cirrhosis were hepatitis B virus (HBV), HCV, alcoholic liver disease (ALD), and autoimmune liver disease, with a total of 77,966 patients diagnosed with these diseases in the past 12 years
Cirrhosis refers to end-stage liver disease, which is caused by multiple factors
Summary
Viral hepatitis, especially chronic hepatitis B (CHB), is still a main reason of liver-related morbidity and mortality in China. While the prevalence of hepatitis B virus (HBV) infections fell from 10% to 7% between 1992 and 2006 as a result of a national HBV vaccination program [1]. In addition to ALD, the prevalence of autoimmune liver disease and druginduced liver injury is increasing in China. Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. The top four etiologies of cirrhosis were HBV, HCV, ALD, and autoimmune liver disease. In Beijing 302 Hospital, the top four etiologies of cirrhosis were HBV, HCV, ALD, and autoimmune liver disease. Over the last 12 years, the prevalence of HBV cirrhosis has decreased gradually, whereas that of alcoholic cirrhosis has increased significantly
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