Abstract
Some lipid compounds of the human erythrocite stroma were studied in three groups of premature newborn infants fed different milk formulae. Two blood samples were obtained: immediately after birth and 20 days of feeding a given formula. Three milk formulae with a widely different linoleate content were used A=6, 08%, B=15,98%, C=0, 6% of the total caloric intake). Free cholesterol which decreased after feeding A apd B, did not vary after C, because of its low 18:2w6 concentration. In choline phosphoglycerides a clear sign of essential fatty acid deficiency was found in the infants fed C: a striking very significant increase of the triene/tetraene ratio(20:3W9 / 20:4W6) not only in plasma but also in red cell stroma. An increase of 18:1W9 was also found, accompanying a very low percentage of 18:2W6 in the group fed formula C. It is concluded that a content of acid linoleic in the infant diet of only 0,6% of the total caloric intake is essential fatty acid deficient.
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