Abstract
THE general concept of lysosomes as separate cytoplasmic organelles was originated by de Duve1 in 1955, when he also demonstrated that acid phosphatase is characteristically present in these structures. Other workers2,3 have determined the cytological location of lysosomes by applying histochemical techniques for acid phosphatase to specially prepared tissue sections. This communication describes changes in the lysosomes of malignant epithelial cells, as shown by staining fresh frozen cryostat sections and exfoliated cell smears for acid phosphatase. The malignant tumours used in this experiment were produced in hamster cheek pouches in response to repeated applications of a chemical carcinogen, in a manner similar to that first described by Salley4.
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