Abstract
Established rat models with subclinical hypothyroidism(SCH)were divided into three groups: subclinical hypothyroid(SCH), SCH treated with levothyroxine(L-T4), and control group. The L-T4 group displayed lowered total cholesterol and endothelin levels compared with the SCH group[(1.29±0.05 vs 2.38±0.55)mmol/L, (98.54±32.43 vs 160.62±37.25)nmol/L, both P<0.05]. Nitric oxide levels, left ventricular systolic pressure, and blood flow in abdominal aorta were significantly higher in the L-T4 group than those in the SCH group. The results of this study indicate that L-T4 treatment may improve endothelial dysfunction and hemodynamic changes in rats with SCH. (Chin J Endocrinol Metab, 2015, 31: 360-362) Key words: Subclinical hypothyroidism; Rat; Levothyroxine; Hemodynamics; Endothelium
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