Changes in emotion following lesions of discrete orbitofrontal cortex subregions in the macaque

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Event Abstract Back to Event Changes in emotion following lesions of discrete orbitofrontal cortex subregions in the macaque Peter Rudebeck1*, Lily Chau1 and Elisabeth Murray1 1 National Institute of Mental Health, United States Marked changes in affect is one of the hallmarks of damage to or dysfunction within the orbitofrontal cortex (OFC) in both humans and animals. The OFC, however, is not a homogeneous structure. It has been proposed that there may be two subregions, distinct by their cytoarchitecture and connections to other brain structures, which make up the OFC. One of these subregions broadly encompasses Walker’s areas 11/13 while the other centers on Walker’s area 14 and there has been speculation that each might play distinct roles in regulating affect. Direct evidence for this hypothesis, however, is scarce. Damage to the OFC in humans is rarely confined to one subregion alone and studies in animals have generally focused on the OFC as a whole. To explore the contribution of these OFC subregions to emotional processing, restricted excitoxic lesions of either areas 11/13 (n=4) or area 14 (n=4) were made in rhesus monkeys (Macaca mulatta). The emotional responses of these two groups as well as a group of unoperated controls (n=4) were assessed in a series of tasks where monkeys were presented with different objects at the same time as a valued food reward. The latency to retrieve the food reward reflects macaques relative valuation of the object in contrast to the incentive value of the food. In the first task monkey’s latency to retrieve the food reward was assessed in the presence of either static neutral objects or static fear objects (rubber snake or spider) whereas in a second task their responses to moving fearful objects were assessed (moving toy snake and spider). Compared to unoperated controls, monkeys with lesions restricted to either areas 11/13 or area 14 were less likely to retrieve the food reward in the presence of the static rubber spider. These preliminary results, which suggest increased fear in both lesion groups are in contrast with previous reports of macaques with more extensive OFC lesions. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Rudebeck P, Chau L and Murray E (2009). Changes in emotion following lesions of discrete orbitofrontal cortex subregions in the macaque. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.282 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Jun 2009; Published Online: 12 Jun 2009. * Correspondence: Peter Rudebeck, National Institute of Mental Health, Bethesda, United States, peter.rudebeck@mssm.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Peter Rudebeck Lily Chau Elisabeth Murray Google Peter Rudebeck Lily Chau Elisabeth Murray Google Scholar Peter Rudebeck Lily Chau Elisabeth Murray PubMed Peter Rudebeck Lily Chau Elisabeth Murray Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.