Abstract
Intraperitoneal injection of 40 μg of dibutyryl cyclic AMP to homozygous Brattleboro rats fasted for 12 hours but having free access to water resulted in an increase in urine flow and in the rates of excretion of Na, K, PO 4 and urea. Similar results were obtained in Brattleboro rats having free access to food and water which received 200 μg of nucleotide. The injection of 20 μg of dibutyryl cyclic AMP or 40 μg 5′-AMP to homozygous Brattleboro rats with free access to food and water or the administration of 40 μg of 5′-AMP to homozygous rats fasted for 12 hours but with free access to water did not alter renal excretion patterns. These results indicate that dibutyryl cyclic AMP may depress tubular reabsorption of water, Na and PO 4 as has been shown to be the case in the intact dog. In homozygous Brattleboro rats fasted for 24 hours but allowed free access to water, 40 μg of dibutyryl cyclic AMP resulted in a tendency to reduced urine flow and diminished excretion of Na, K and urea. The explanation for these results is not apparent from these data.
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