Abstract
The activity of cortical epileptogenic foci induced by focal freezing and topical administration of penicillin was monitored in cats during various phases of alterations in urinary bladder pressure produced by detrusor contractions and passive distention. The control epileptiform spike discharge rate was decreased during all phases of detrusor contractions and during the filling phase of passive distension. In contrast, the spike rate was increased during all remaining phases of passive distension. It was concluded that changes in bladder pressure can modulate the activity of cortical epileptogenic foci. It is suggested that suppression of spike rate is the result of the desynchronizing effects of afferent input related to bladder pressure changes. Motor activity related to detrusor contraction may have a similar, but lesser, effect, and may also produce the precontraction suppression. Enhancement of cortical epileptiform discharge rate may be due to a synchronizing “rebound” effect produced by a sudden reduction of high suppressive levels of afferent activity to very low or zero levels.
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