Abstract
Clusterin (70-80 kDa; synonym ApoJ) is a stress-associated cytoprotective glycoprotein involved in many physiological and pathophysiological processes and it is up-regulated by various apoptotic triggers in many cancers and neurodegenerative diseases. Measurement of serum clusterin values in individuals with a history of cancer before and after spa therapy. Serum clusterin concentration (ELISA) was determined in a group of 26 oncologic patients (4 men and 22 women) at the beginning and at the end (the 18th or 19th day) of spa treatment. The spa treatment lasted 3 weeks. The patients with various types of cancer had undergone basic therapy (surgery, chemotherapy, actinotherapy) prior to spa treatment. They were divided according to the interval between the end of basic treatment and the start of spa therapy. Patients coming within 12 months comprised group A (n=15) while patients coming later comprised group B (n=11). clusterin concentrations increased in 11 patients (73%) and decreased in 4 (27%) in group A and increased in 5 (45%) and decreased in 6 (55%) in group B. The non-parametric sign test was non-significant. There were positive value of average change between the second and the first sample in group A and negative value in group B. In group A the parametric test showed significant increased clusterin concentration at the end of spa treatment but the data had non-parametric distribution in fact. It is concluded that early spa therapy increases clusterin serum concentration. This is probably due to to the positive effects of balneotherapy. However the sample was very small and further research is required.
Highlights
In the Czech Republic, cancer patients are sent to spas for further complex treatment after basic therapy
The basic complex spa therapy of oncologic patients lasted in this case 3 weeks and the patients underwent 1821 treatment procedures per week
Thirty-one patients were initially selected for the research. They were sent to Luhacovice Spa after cancer diagnosis, only one (No.26) had bronchial asthma as her main diagnosis (J45.9) but she was treated for pharynx carcinoma 18 months prior to the spa treatment
Summary
In the Czech Republic, cancer patients are sent to spas for further complex treatment after basic therapy (surgery, actiontherapy, chemotherapy). The basic complex spa therapy of oncologic patients lasted in this case 3 weeks and the patients underwent 1821 treatment procedures per week. The typical treatment programme in Luhacovice Spa consists of carbonated baths (3 times per week), conventional massage (3 times per week), water gymnastic The individual plan is prescribed by a spa physician on the basis of incoming physical examination, the physician takes into account both the basic diagnosis and other health problems as well as current health status. When clinically examined at the end of spa therapy, the patients showed an improvement both in mental and physical condition (joint mobility, cardio-pulmonary fitness, scar tissue release, etc.). Clusterin (70-80 kDa; synonym ApoJ) is a stress-associated cytoprotective glycoprotein involved in many physiological and pathophysiological processes and it is up-regulated by various apoptotic triggers in many cancers and neurodegenerative diseases
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