Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1–40) protein

Abstract

We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1–40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1–40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1–40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1–40) in the brain may affect CNTF production in vivo.