Abstract
Changes in serum concentrations of interferon-γ (INF-γ), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), immunoglobulin Е (IgE), С-reactive protein and in clinical status of patients with virus-induced exacerbation of bronchial asthma were studied before and after treatment with basic medications and interferon inductor tiloron. A positive influence of Tiloron on clinical signs and immunologic parameters, such as IL-4, TNF-α, INF-γ, IgE, and С-reactive protein, was found in 95 % of patients with moderate asthma. Thus, serum concentrations of these biomarkers in asthma patients could be used as an index of inflammatory response reflecting severity of the pathology and as an important criterion to choose the individual treatment.
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