Abstract
1. 1. Resistance to concanavalin A was accompanied by modifications to the fundamental growth and membrane-associated properties of two concanavalin A-resistant cell lines which were independently selected by either single step or cycling procedures. 2. 2. Using the galactose-oxidase [ 3H]borohydride surface labelling procedure, several modifications in surface glycoproteins were detected on variant cells when compared to parental wild type cells; a prominent difference was the presence of an additional surface component, with an apparent molecular weight of 155,000 on variant cells which was missing from both wild type populations. 3. 3. These observations provide strong support for the view that modified cell surface glycoproteins are directly involved in the complex concanavalin A-resistant phenotype which includes changes to some fundamental biological properties; concanavalin A-resistant variants provide an opportunity to correlate changes in membrane function with modifications in membrane structure.
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