Abstract
Introduction This study was undertaken to observe changes in cardiac parameters along with clinical and laboratory changes after renal transplantation. Patients and Methods Cardiac parameters were evaluated by M-mode 2-dimensional echocardiography before transplantation and at monthly intervals. All subjects had functioning grafts at the time of the evaluations. Results Fifty-two allograft recipients underwent pretransplant parameters for comparison to those at posttransplant months 1, 3, 6, and 12. When changes at month 1 and 3 were observed among 22 patients, improvements were evident at month 3. Comparisons of pretransplant versus month 3 showed systolic blood pressure (SBP), 161 ± 16 to 133 ± 26 mmHg ( P < .002); diastolic BP (DBP), 101 ± 9 to 86 ± 11 mmHg, ( P < .006); hemoglobin (Hgb), 7.3 ± 1.6 to 11.2 ± 3.9 g/dL ( P < .006); left atrial diameter (LAD), 41 ± 5 to 35 ± 3 mm ( P < .001); left ventricular muscle mass index (LVMI), 379 ± 114 to 248 ± 58 g/m 2 ( P < .001); and left ventricular end diastolic volume index (LVEDVI), 96 ± 28 to 64 ± 17 mL/m 2 ( P < .002). When changes at months 3, 6, and 12 were observed among 30 patients, improvements evident at month 3 were maintained. Comparisons of pretransplant and 3 and 12 months observations showed SBP, 157 ± 17, 131 ± 14, to 126 ± 10 mm Hg ( P < .001); DBP, 97 ± 10, 83 ± 16, to 85 ± 6 mmHg ( P < .001); Hgb, 7 ± 1, 13 ± 2, to 13 ± 2 g/dL ( P < .001); LAD, 39 ± 7, 35 ± 3, to 34 ± 4 mm ( P < .05); LVMI, 275 ± 91, 191 ± 38, to 159 ± 26 g/m 2 ( P < .001); and LVEDVI, 87 ± 29, 56 ± 34, to 49 ± 24 mL/m 2 ( P < .001). Conclusion Significant improvements in cardiac parameters were evident by the third month post-renal transplantation; the changes were maintained over a longer period among patients with functional grafts.
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