Abstract

 
 
 The purpose of the research was to study the changes in adipocytokines in patients with alcoholic liver cirrhosis (ALC) associated with non- alcoholic fatty liver disease (NAFLD) depending on the stage of decompensation. A significant increase in immunoreactive insulin, the HOMA-IR index and a decrease in the QUICKI index in patients II gr. in comparison with patients I gr. has been detected, that indicating insulin resistance (p<0.05). On the basis of the results of the analysis of the correlation between the levels of leptin, adiponectin, resistin and carbohydrate metabolism, it was found that a stronger correlation was observed in patients suffering from ALC associated with NAFLD.
 
 
Highlights
According to the literature, alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are two hepatic diseases with similar pathogenetic mechanisms of the development, progression and histological characteristics
In patients with alcoholic liver cirrhosis (ALC) associated with NAFLD, the course of the disease is more severe, it is accompanied by more severe clinical signs and disorders of carbohydrate metabolism
On the basis of the results of the analysis of the correlation between the levels of leptin, adiponectin, resistin and carbohydrate metabolism, it was found that a stronger correlation was observed in patients suffering from ALC associated with NAFLD
Summary
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are two hepatic diseases with similar pathogenetic mechanisms of the development, progression and histological characteristics. Staging of the pathological condition is the result of complex interaction, which involves the population of the liver cells (parenchymal and nonparenchymal), and pathological signals coming from other organs such as fatty tissue and the gastrointestinal tract Such stimuli include the death of hepatocytes, biologically active substances and intestinal pathogens secreted by adipose tissue 6(36), June 2019. Which contribute to inflammation and fibrogenesis by activating macrophages (Kupffer cells), which, in turn, activate leukocytes and star cells (Ito cells, lipocytes) with subsequent excessive production of the extracellular matrix components [3] Both ALD and NAFLD are associated with a lipid metabolism disorder. Such ectopia and large amount of FFA in the body result in a decrease in insulin sensitivity and the development of glucose- and lipo-toxicity The consequence of these processes is a disorder of the synthesis of adipokines, which affect the metabolic processes and the formation of oxidative stress. Some adipocytes are proinflammatory cytokines, some are involved in the metabolism of glucose and lipids, and others affect the complement system and vascular hemostasis [6]
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