Abstract
The effect of 0.5, 1 and 1.5 per cent inspired halothane concentrations on myocardial blood flow has been studied using a xenon-133 clearance technique in 12 dogs anaesthetized with pentobarbitone 30 mg/kg body weight. Halothane was found to reduce cardiac output, mean systemic arterial pressure, myocardial blood flow and oxygen consumption in proportion to its inspired concentration. With the higher concentrations of halothane, there was a small increase in myocardial vascular resistance associated with a small, significant reduction in coronary sinus Po2 and oxygen content.
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