Abstract
The changes in total blood calcium fractions were investigated in 20 infants and neonates undergoing open-heart surgery for correction of congenital heart defects. On initiation of cardiopulmonary bypass (CPB), total serum calcium fell from 2.29 ± 0.05 mmol/I to 1.8 ± 0.04 mmol/I and there was a profound fall in biologically active ionized calcium from 1.26 ± 0.02 mmol/I to 0.49 ± 0.04 mmol/l. Protein-bound calcium also fell from 1.03 ± 0.07 mmol/I to 0.09 ± 0.03 mmol/l. Complexed calcium increased from 0.08 ± 0.02 mmol/I to 1.1 ± 0.05 mmol/l. The large fall in ionized calcium and increase in complexed calcium could be accounted for by the corresponding large increases in serum citrate (162.2 ± 29.8 μmol/l to 1689.8 ± 163.1 μmol/l) and serum lactate (1.27 ± 0.18 mmol/I to 7.79 ± 0.72 mmol/l). All measured fractions of calcium returned towards their pre-operative levels by the end of bypass. However, 13 of the 20 patients had less than optimal levels of ionized calcium when being weaned from bypass despite the empirical use of intravenous calcium supplements. This study demonstrates that ionized calcium can be quickly and easily measured in the peri-operative period, that there can be extremely large changes in calcium fractions during CPB in infants and neonates, and that ionized calcium can be unexpectedly low in the critical period when weaning patients from bypass. Total calcium measurements gave an inaccurate estimate of the ionized calcium fraction.
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