Changes in c-FOS Protein Levels in Some Basal Ganglia of Rats before and after Vestibular Stimulation

Abstract

Objective: To analyse the changes in the levels of c-FOS protein in some basal ganglia ganglia of rats before and after vestibular stimulation. Methods: Rats were selected as the study subjects and non-invasive electrical stimulation was used to understand the function between the vestibular organs and the ganglia and the issue of changes in the receptor mechanism of c-FOS protein in the ganglia. Results: After stimulation of the rat vestibular organ, there was a significant trend towards higher expression of c-FOS positive neurons in the MVN region, along with a similar increase in the number of immunopositive neurons in the PF region. Although no direct nerve fibre connection was found between the MVN and CPu, this index was also observed considering that CPu would be involved in motor regulation, and the results also showed a significant increase in positive neuronal expression in the observation group of rats. The results showed that c-FOS positive neuronal expression in all three regions increased after non-invasive stimulation of the vestibular organ, with statistically significant differences (P<0.05). Conclusion: Stimulation of peripheral vestibular organs can induce functional changes in the basal ganglia and c-FOS protein-positive neuronal expression, giving a good therapeutic reference for future Parkinson's disease and modulating vestibular function in patients.