Abstract
Rats fasted for 24 hrs. were fed for two hours after which time food was removed. Food intake decreased brain 5-HIAA and tryptophan levels by about 22% and 27%, respectively, but did not modify brain serotonin concentration. These changes persisted for about six hours. The synthesis rate of brain serotonin was about 30% lower in rats fed for two hours than in rats fasted for 24 hours. Food intake produced changes in plasma tryptophan opposite to those produced in brain. Feeding also decreased brain serotonin turnover in hypophysectomized rats.
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