Abstract
The intraventricular injection of 5,6-dihydroxytryptamine into desipramine-treated rats caused a marked reduction in serotonin levels 5 and 10 days after treatment without significantly affecting catecholamine levels. In these animals, total leukocytes were increased and lymphocytes decreased. The number of helper T-cells ( W3 25 + ) was significantly decreased after 5 days, whereas the numbers of total T-cells ( W3 13 + ) and suppressor T-cells (MRC OX8) were increased after 10 days. The percentages of total T-cells, helper T-cells and suppressor T-cells were significantly reduced after 5 days. Natural killer cell (NK) activity was markedly reduced after 5 days. This finding suggests that central serotonin-containing neurons might be involved in the regulation of certain parts of the peripheral immune system.
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