Abstract
Purpose: To investigate the effects of combined jumping exercise and honey supplementation on bone metabolism and antioxidant status in female rats. Methods: Forty eight 12-week old Sprague Dawley female rats were divided into four groups: control group (C), honey group (H), jumping group (J), and combined jumping and honey group (JH). Jumping exercise consisted of 40 jumps/day for 5 days/week at a height of 40 cm. Honey was given to the rats at a dosage of 1 g/kg body weight/rat/day via force feeding for 7 days/week. At the end of the study, tibial proximal volumetric total Bone Mineral Density (BMD) and volumetric trabecular BMD, serum total calcium, serum Alkaline Phosphatase (ALP) (bone formation marker), serum C-terminal telopeptide of type 1 procollagen (1CTP) (bone resorption marker), serum F 2 -isoprostanes (oxidative stress marker) and serum Total Antioxidant Status (TAS) were measured. Results: There were no significant differences in tibial proximal volumetric total BMD and volumetric trabecular BMD among all the groups. Eight weeks of jumping exercise and honey supplementation resulted in statistically significant higher serum total calcium concentration in JH group as compared to C, H and J groups (p < 0.05). Serum ALP was significantly higher in J group as compared to C group (p < 0.05). On the other hand, serum 1CTP was significantly lower in JH as compared to the other three experimental groups. The concentration of F2-isoprostanes was not statistically different among all the groups. Serum TAS was significantly higher in JH and H groups as compared to C group (p < 0.05) respectively. Conclusion: The results of the present study showed that 8 weeks of jumping exercise and honey supplementation significantly reduced bone resorption and enhanced antioxidant status, but did not seem to elevate oxidative stress marker.
Highlights
Physical activity is reported as one of the strategies for maximizing bone mass during early age and subsequently minimizing bone loss later in life [1,2]
There were no significant differences in initial body weight between all the experimental groups
No significant differences were found in the final body weight of the rats among the groups, where the final body weight of the rats in C, H, J and jumping and honey group (JH) was 227.6 ± 14.6 g, 232.9 ± 18.1 g, 226.1 ± 16.5 g and 224.7 ± 13.8 g respectively
Summary
Physical activity is reported as one of the strategies for maximizing bone mass during early age and subsequently minimizing bone loss later in life [1,2]. The effect of physical activity is through modification in bone turnover which occurs through two fundamentally different processes, i.e. modeling and remodeling with the activities of osteoblast and osteoclast cells in the mechanisms of bone formation and bone resorption [3]. The mechanisms by which combined exercise and dietary intake lead to changes in bone metabolism are not fully understood. Nutritional supplementation is another main factor associated with bone health and development. The effects of different types of supplementation such as calcium, vitamin D, milk, soy and soy protein on bone mass, turnover and mineral density have been reported [6,7,8,9]. It was hypothesized that honey may play a role in increasing bone health
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
