Changes in BMI, Duration of Overweight and Obesity, and Glucose Metabolism: 45 Years of Follow-up of a Birth Cohort

Abstract

OBJECTIVELong-term implications of childhood obesity and BMI change over the life course for risk of type 2 diabetes remain uncertain. The objective was to establish whether there are effects on adult glucose metabolism of 1) sensitive periods of BMI gain or 2) long duration of overweight and obesity.RESEARCH DESIGN AND METHODSParticipants in the 1958 British birth cohort with child to adult BMI and glycosylated hemoglobin (HbA1c) at 45 years (n = 7,855).RESULTSPrevalence of type 2 diabetes or HbA1c ≥7 was 2%. BMI gains in child- and adulthood were associated with higher HbA1c: for every SD of 5-year BMI increase from 0 to 7 years, there was a 75% (95% CI 1.42–2.16) increased risk of HbA1c ≥7, increasing to a 4.7-fold (3.12–7.00) risk for the interval 23–33 years. Associations for BMI gain in adulthood were related to attained BMI but were independent for the longer period birth (or 7 years) to 45 years. Duration of obesity was also associated with HbA1c; compared with the never obese, those with childhood onset had a 23.9-fold risk (13.5–42.1) of HbA1c ≥7%; odds ratios were 16.0 (10.6–24.2) and 2.99 (1.77–5.03), respectively, for young and midadulthood onset. Similar trends by onset age were found in mean HbA1c levels and for onset of overweight. Those with the earliest age of onset had higher BMI and waist circumference at 45 years, which markedly explained the associations for onset age and HbA1c.CONCLUSIONSExcessive BMI gain across the life span and earlier onset of overweight/obesity are associated with impaired glucose metabolism, in part through attained adult BMI.