Changes in Blood Components in Aphtha Patients with Excess Heat.

Lu Qin,Jinjun Ji,Yongsheng Fan,Li Xu,Yifeng Jiao,Guanqun Xie,Danqing Fu,Yan Li,Li Ye

doi:10.1155/2016/7219257

Abstract

“Superior heat” is a popularization expression in TCM heat syndrome and has no counterpart in the modern medical system concept. Oral ulcer is considered to be a kind of clinical manifestation of “superior heat.” Aphtha is a common and frequently occurring disease, which can be divided into excess heat and Yin deficiency. The aphtha of excess heat manifests the syndromes of acute occurrence, severe local symptoms, obvious swelling and pain, red tongue, yellow coating, and fast-powerful pulse. In this study, we found that there was an abnormal immune regulation in aphtha patients induced by excess heat. There are changes in the blood components, including abnormal serum protein expression (IL-4, MMP-19, MMP-9, and Activin A) and a higher percentage of CD4+CD25+Treg cells in the peripheral blood lymphocytes of the EXP group. Changes in the blood environment may be an important factor in the occurrence of aphtha caused by excess heat.

Highlights

“Superior heat” is often used to describe mouth sores, sore throat and gums, and other physical symptoms
The expression levels of IL-4, Matrix metalloproteinases (MMPs)-19, and Activin A are closely related to the occurrence of oral ulcers. In the latter part of the experiment, we found that MMP-9 was abnormally expressed in the excess heat period of oral ulcers
The results showed a variety of differential expression proteins in aphtha patients, including four types of proteins with significant rising and three types of proteins with significant reduction (Table 1)

Summary

Introduction

“Superior heat” is often used to describe mouth sores, sore throat and gums, and other physical symptoms. The aphtha of yin deficiency is characterized by internal heat due to yin deficiency as a long course, mild local symptoms, repeated attacks, mild swelling and pain, a red tongue with little fluid, scanty coating or no coating, and a thin and fast pulse, sometimes combined with hot flashes, night sweat, emaciation, dry throat and mouth, dysphoria with feverish sensation in the chest, palms, and soles, and other symptoms [5] This type of syndrome classification provides the basis for clinical treatment. Evidence-Based Complementary and Alternative Medicine chip [7], a type of protein chip, has the antibody fixed on the surface of the solid phase carrier and captures the antigen in the sample through a specific immune response It can detect the expression abundance of hundreds of proteins simultaneously. The relative expression levels of the proteins were quantified by densitometry

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