Abstract
In an attempt to elucidate the causes of the increased tendency to thrombosis in the nephrotic syndrome, changes in blood coagulation, fibrinolysis and biochemical function were measured in a group of patients with clinical and biochemical evidence of the nephrotic syndrome. These patients showed significant elevation of factor V, factor VIII, fibrinogen, plasminogen and α2-macroglobulin, while levels of antiplasmin activity and α1-antitrypsin were lowered. Fibrinogen, cholesterol, and antithrombin activity correlated significantly with each other as did levels of serum albumin, antiplasmin, and α1-antitrypsin. It appears that these changes take place passively as a result of increased protein synthesis and urinary loss of low molecular weight protein and not from primary changes in the coagulation or fibrinolytic mechanisms.
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