Abstract
BackgroundSeveral neuroimaging studies have reported neurophysiological alterations in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often.MethodsWe investigated background EEG activity changes after six months of oxcarbazepine treatment to better understand the neurophysiological alterations and progression that occur in BCECTS. In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions.ResultsBackground EEG activity for the delta frequency band was significantly decreased in the fronto-temporal and limbic regions of the left hemisphere after oxcarbazepine treatment (threshold log-F-ratio = ±2.729, P < 0.01). The maximum current density difference was found in the parahippocampal gyrus of the left limbic lobe (Montreal Neurological Institute coordinate [x, y, z = 25, − 20, − 10], Brodmann area 28) (log-F-ratio = 3.081, P < 0.01).ConclusionsOur results indicate the involvement of the fronto-temporal and limbic cortices in BCECTS, and limbic lobe involvement, including the parahippocampal gyrus, was noted. In addition to evidence of the involvement of the fronto-temporal and limbic cortices in BCECTS, this study also found that an antiepileptic drug could reduce the delta frequency activity of the background EEG in these regions.
Highlights
Several neuroimaging studies have reported neurophysiological alterations in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS)
To better understand the neurophysiological alterations and their development in BCECTS, the present study investigated changes in background EEG activity after six months of oxcarbazepine treatment, which is considered the drug of choice in BCECTS [3]
There were no significant differences in the background EEG activity between the untreated and treated conditions
Summary
Several neuroimaging studies have reported neurophysiological alterations in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS). Reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Background electroencephalography (EEG) in cases of BCECTS has not been performed often. Centrotemporal spikes observed on electroencephalography (EEG) are the hallmark of BCECTS [2]. Several neuroimaging studies using EEG and functional magnetic resonance imaging (MRI) have reported neurophysiological alterations in BCECTS, but the reported outcomes have been inconsistent, and the progress of alterations in the brain remains unresolved. Altered EEG characteristics in BCECTS are mostly studied with respect to qualitative aspects of epileptic activity, whereas background activity in the interictal period is often not quantified [13]
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